Information Packages
Avian Influenza
The U.S. Government is concerned that the ongoing outbreaks of avian influenza in birds have the potential to turn into a human influenza pandemic that would have significant global health, economic, and social consequences. The President's November 2005 National Strategy for Pandemic Influenza assigned the lead role for the U.S. Government's international efforts in dealing with avian and pandemic influenza to the Department of State.
The Under Secretary for Democracy and Global Affairs has developed the Avian Influenza Action Group to be headed by the Special Representative for Avian and Pandemic Influenza. The Avian Influenza Action Group, in close collaboration with the Departments of Health and Human Services, Agriculture, Homeland Security, Defense, the U.S. Agency for International Development, and other agencies, leads the Department's work on developing an international engagement strategy based on preparedness, prevention, and containment.
The Avian Influenza Action Group is involved in efforts to: engage political leadership in affected nations through bilateral interactions and multilateral forums; strengthen transparency and international cooperation; improve surveillance and laboratory capacity; strengthen coordination between human and animal health sectors; and develop coordination of concerned countries.
All involved agencies throughout the U.S. Government are coordinating to maintain up-to-date U.S. information on pandemic flu and avian influenza at pandemicflu.gov. The State Department's Bureau of Consular Affairs will keep international travelers up to date through their travel fact sheet.
Latest Techical Information (WHO):
To date, there have been 21 confirmed cases of avian influenza in Turkey. The majority of these cases have been in the district of Dogubeyazit in Agri Province in the eastern part of the country. Four of these cases have been fatal: All four were residents of Dogubeyazit. The Turkish government has launched an intensive public education campaign and rapid surveys conducted in the most severely affected eastern part of the country have shown that there is an almost universal awareness of the disease and of the risk factors for infection. This awareness has been accompanied by behavioral changes that are expected to reduce opportunities for human infections to occur. As the virus is now known to be present in many parts of the country, some additional human cases should be anticipated in the immediate future. The number of cases is, however, expected to decline as high-risk behaviors become less common and culling operations, which are presently under way, reduce the number of infected birds.
HOW DO PEOPLE BECOME INFECTED?
Direct contact with infected poultry, or surfaces and objects contaminated by their feces, is presently considered the main route of human infection. To date, most human cases have occurred in rural areas where many households keep small poultry flocks, which often roam freely, sometimes entering homes or sharing outdoor areas where children play. As infected birds shed large quantities of virus in their feces, opportunities for exposure to infected droppings or to environments contaminated by the virus are abundant under such conditions. To date, there have been no known cases of human-to-human transmission in Turkey.
IS IT SAFE TO EAT POULTRY AND POULTRY PRODUCTS?
Yes, though certain precautions should be followed. Poultry and poultry products can be safely consumed provided these items are properly cooked and properly handled during food preparation. The H5N1 (avian influenza) virus is sensitive to heat. Normal temperatures used for cooking (140 degrees F in all parts of the food) will kill the virus. Consumers need to make sure that all parts of the poultry are fully cooked (no ‘pink’ parts) and that eggs, too, are properly cooked (no ‘runny’ yolks). Juices from raw poultry and poultry products should never be allowed, during food preparation, to touch or mix with items eaten raw. When handling raw poultry or raw poultry products, persons involved in food preparation should wash their hands thoroughly and clean and disinfect surfaces in contact with the poultry products. Soap and hot water are sufficient for this purpose.
Avian influenza is not transmitted through cooked food. To date, no evidence indicates that anyone has become infected following the consumption of properly cooked poultry or poultry products, even when these foods were contaminated with the H5N1 virus.
Adapted from the World Health Organization.
Naomi Uludamar, Health Unit, Ankara, January 2006
Questions and Answers on Avian Influenza
(Adapted from the U.S. Centers for Disease Control and Prevention and the World Health Organization websites)
Question: What is an avian influenza A (H5N1) virus?
Influenza A (H5N1) virus - also called "H5N1 virus" - is an influenza A virus subtype that occurs mainly in birds. It was first isolated from birds (terns) in South Africa in 1961. In 2003, a strain of H5N1 emerged in Asia that was highly deadly among poultry. This virus quickly spread to other bird species. While infection has been concentrated in Southeast Asia, the H5N1 virus has the potential to circulate among birds worldwide. For detailed information about avian influenza, visit the U.S. Centers for Disease Control and Prevention in Atlanta (CDC-Atlanta) website at http://www.cdc.gov/flu/avian/gen-info/facts.htm or the World Health Organization (WHO) website at http://www.who.int/csr/disease/avian_influenza/avian_faqs/en/index.html
or the Food and Agriculture Organization of the United Nations (FAO) website at http://www.fao.org/ag/againfo/subjects/en/health/diseases-cards/special_avian.html
Question: What is the H5N1 bird flu that has recently been reported in Asia?
Outbreaks of influenza H5N1 occurred among poultry in eight countries in Asia (Cambodia, China, Indonesia, Japan, Laos, South Korea, Thailand, and Vietnam) during late 2003 and early 2004. At that time, more than 100 million birds in the affected countries either died from the disease or were killed in order to try to control the outbreak. By March 2004, the outbreak was reported to be under control. Beginning in late June 2004, however, new deadly outbreaks of influenza H5N1 among poultry were reported by several countries in Asia (Cambodia, China, Indonesia, Malaysia, Thailand, and Vietnam). It is believed that these outbreaks are ongoing. Human infections of influenza A (H5N1) have been reported in Thailand, Vietnam, Cambodia, and Indonesia.
Question: What is the risk to humans from the H5N1 virus?
The H5N1 virus does not usually infect humans. In 1997, however, the first case of infection from a bird to a human was identified during an outbreak of bird flu in poultry in Hong Kong. The virus caused severe respiratory illness in 18 people, 6 of whom died. Since that time, there have been other cases of H5N1 infection among humans. Most recently, human cases of H5N1 infection have occurred in Thailand, Vietnam, Cambodia, and Indonesia. The Case Fatality Rate (CFR) prior to March 2005 was around 70% but has since dropped to 50 percent. Almost all cases to date have occurred after direct contact with infected poultry or contaminated surfaces. Less than 5 cases have been attributed to person-to-person ransmission. So far, spread of H5N1 virus from person to person has been rare. However, ecause all influenza viruses have the ability to change, scientists are concerned that the 5N1 virus could become more adapted within humans and then more easily spread from one person to another. Because these viruses do not commonly infect humans, there is little or no immune protection against them in the human population. If the H5N1 virus were able to infect people and spread easily from person to person, an "influenza pandemic" (worldwide outbreak of disease) could begin. No one can predict when a pandemic might occur. However, experts from around the world are watching the H5N1 situation in Asia very closely and are preparing for the possibility that the virus may begin to spread more easily and widely from person to person.
Question: What is the current situation in Turkey regarding Avian Influenza? Is
this an Epidemic? Updated October 13, 2005
On October 1, 2005 Turkish officials reported an outbreak of Avian Influence affecting only poultry on a farm. Tests are ongoing to determine which strain of Avian Influenza is present in Turkey. It is not yet known whether the H5N1 strain is responsible. There have been no reported cases of human illness or death in Turkey.
Question: How is infection with H5N1 virus in humans treated?
Currently no vaccine has been approved to provide protection against the H5N1 strain currently in Asia, although a number of candidates are in development. Anti-viral compounds such as amantadine, rimantadine, zanamavir and oseltamavir (Tamiflu) have shown some efficacy against other Influenza A viruses, and an initial study using oseltamavir on mice suggests that it may be effective against H5N1. However, some of the H5N1 virus subtypes in Southeast Asia possess a mutation that would suggest that they are less sensitive to some antiviral compounds.
Question: Should I begin taking antiviral medications such as Tamiflu if I'm planning a visit to Turkey? Is Tamiflu available in Turkey?
Travelers coming to Turkey should consider scheduling an appointment with their health care provider before leaving the U.S. to discuss risks for potential exposure to H5N1. Risk of exposure and the decision to take a drug like Tamiflu, which, as yet, has no proven role for preventing human H5N1 infections must be determined on a case-by-case basis. Only you and your health care provider can determine that risk and what the most appropriate precautions are for you. Tamiflu (oseltamivir) is available in Turkey.
Question: Is there a vaccine to protect humans from H5N1 virus?
There currently is no vaccine to protect humans against the H5N1 virus that is being seen in Asia. However, vaccine development efforts are under way. Research studies to test a vaccine to protect humans against H5N1 virus began in April 2005. (Researchers are also working on a vaccine against H9N2, another bird flu virus subtype.) For more information about the H5N1 vaccine development process, visit the National Institutes of Health website.
Question: What are the symptoms of bird flu in humans?
Symptoms of bird flu in humans have ranged from typical flu-like symptoms (fever, cough, sore throat and muscle aches) to eye infections, pneumonia, severe respiratory diseases< (such as acute respiratory distress), and other severe and life-threatening complications. The most consistent symptoms include fever (>38°C or >100.4°F) and a respiratory syndrome including a non-productive cough and sore throat.
Question: How does bird flu spread?
Infected birds shed flu virus in their saliva, nasal secretions, and feces. Susceptible birds become infected when they have contact with contaminated excretions or surfaces that are contaminated with excretions. It is believed that most cases of bird flu infection in humans have resulted from contact with infected poultry or contaminated surfaces.
Question: What is the risk to humans from bird flu? The risk of H5N1 is considered quite low for most people.
Care should be taken, however, at times of outbreak among poultry (domesticated chicken, ducks, turkeys, etc.). There is a possible risk to people who have contact with infected birds or surfaces that have been contaminated with excretions from infected birds. The current outbreak of avian influenza A (H5N1) among poultry in Asia is an example of a bird flu outbreak that has caused human infections and deaths. In such situations, people should avoid contact with infected birds or contaminated surfaces, and should be careful when handling and cooking poultry.
Question: Is it safe to eat poultry and eggs in Turkey?
There have been no reported human cases of AI contracted from poultry or egg consumption. Nevertheless, best practices during handling of raw poultry meat and usual recommended cooking practices for poultry products should be followed to lower the risk of common bacterial diseases spread by poor handling and cooking techniques. Eggs from infected poultry could also be contaminated with the virus and therefore care should be taken in handling shell eggs or raw egg products.
Recommended good hygienic practices to avoid spreading of the virus through food (adapted from the World Health Organization 5 Keys to safer food):
• Separate raw meat from cooked or ready-to-eat foods to avoid contamination:
Do not use the same chopping board or the same knife.
Do not handle both raw and cooked foods without washing your hands in between and do not place cooked meat back on the same plate or surface it was on before cooking.
• Do not use raw or soft-boiled eggs in food preparations that will not be heat treated/cooked.
• Keep clean and wash your hands: after handling frozen or thawed raw chicken or eggs, wash thoroughly with soap your hands, surfaces and utensils that have been in contact with the raw meat.
• Cook thoroughly: Thorough cooking of poultry meat will inactivate the viruses. Either ensure that the poultry meat reaches 70°C (160°F) or that the meat is not pink. [Note: USDA/FSIS recommends 180 degrees Fahrenheit for whole turkey/chicken, thighs or wings and 170 degrees Fahrenheit for chicken and turkey breasts]. Egg yolks should not be runny or liquid.
For more information about avian influenza and food safety issues, visit the World Health Organization (WHO) food safety website at http://www.who.int/foodsafety/micro/avian1/en/
Question: Are other animals at risk for H5N1 infection?
Evidence of H5N1 virus has been found in a variety of domestic and wild fowl, pigs, and domestic and wild cats.
Question: What precautions should I take if I live in an area affected by bird flu?
The spread of bird flu in affected areas can normally be prevented.
People should avoid contact with chickens, ducks or other poultry -and their waste – unless absolutely necessary.
Children are at higher risk because they may play where poultry are found. Teach your children the following basic guidelines:
Avoid contact with any birds, their feathers, feces and other waste.
Do not keep birds as pets.
Wash hands with soap and water after any contact.
Not to sleep near poultry.
Do not transport live or dead chickens, ducks or other poultry from one place to another even if you think your birds are healthy.
Handling of poultry in affected areas should be done within the area without transporting them to other areas.
Do not prepare poultry from affected areas as food for your family or animals. The slaughter and preparation of such birds for food is dangerous.
If you unintentionally come into contact with poultry in an affected area, such as touching the bird's body, touching its feces or other animal dirt, or walking on soil contaminated with poultry feces:
wash your hands well with soap and water after each contact;
remove your shoes outside the house and clean them of all dirt; and
check your temperature for 7 days at least once daily. If you develop a high temperature (>37.5°C or (>99.5°F), visit a doctor or the nearest health care facility immediately.
For more information about living in affected areas and possible contact with infected animals, visit the WHO website at http://www.who.int/csr/disease/avian_influenza/en/
Question: What are the travel recommendations regarding the Avian Influenza bird flu outbreak in Turkey?
The strain of AI in Turkey has not yet been identified and there are no specific travel recommendations in affect. The U.S. CDC-Atlanta currently advises that travelers to countries in Asia with known outbreaks of influenza A (H5N1) avoid poultry farms, contact with animals in live food markets, and any surfaces that appear to be contaminated with feces from poultry or other animals. For more information about travel recommendations, visit the CDC-Atlanta website at http://www.cdc.gov
Question: How is the U.S. Government helping to address the Avian Influenza problem?
In recognition of the nature of the AI threat and to support the international response to the H5N1 virus, the U.S. Congress appropriated in June 2005 $25 million dollars to help contain and prevent its spread in the Asia region. A team of experts from CDC, U.S. Department of Agriculture (USDA) and USAID recently concluded an assessment visit to the region. The U.S. has proposed an "International Partnership on Avian and Pandemic Influenza" (IPAPI) to address the emerging threat of AI. We hope to bring together countries to improve worldwide readiness by elevating the issue on national political and social agendas, coordinating efforts among donor and affected nations, and mobilizing and leveraging resources.
Avian Influenza - Controlling Risks from Bird Droppings, Bird Carcasses, and House Cats
BIRD DROPPINGS
1. Birds infected with AI excrete the virus in their droppings, where the virus can survive for long periods, especially when temperatures are near or below freezing. Although there is minimal risk of humans becoming infected by AI from bird droppings (the majority of human cases have resulted from extensive contact with live poultry), as a precautionary measure the following guidelines should be followed when removing bird droppings, even in regions where there has been no documented case of AI. Bird droppings can contain infectious agents other than AI, and so these guidelines represent good practice in any case. (Note: These guidelines apply to the removal of thin coatings of droppings. Thick amounts of droppings -- i.e., those that would require removal using a shovel -- should be removed only by trained staff in consultation with the Post Occupational Safety and Health Officer (POSHO) or other applicable post official. POSHOs and others needing guidance on removal of thick amounts of droppings should
-- Wear gloves that are either disposable or easily cleanable (for example, light-weight vinyl or nitrile gloves, or heavy duty dishwashing rubber gloves).
-- Gently spray the droppings with water or preferably a disinfecting solution made from 3 tablespoons of household bleach per gallon of water. Allow time for the bird droppings to soften.
-- Surgical masks should be worn if removal will aerosolize the droppings; i.e., cause the droppings to turn to airborne dust.
-- Remove the droppings with a disposable or cleanable utensil.
-- If dust is observed as the droppings are disturbed, stop and wet the droppings again before continuing the clean up.
-- Place the droppings, tainted debris, and tools into a plastic bag and seal the bag.
-- Clean re-usable utensils with water and detergent or preferably a disinfectant solution as described above.
-- Clean the exterior of footwear with detergent and water or the disinfectant solution.
-- Rinse reusable gloves with detergent and water or disinfectant solution prior to removing. Disposable
contaminated gloves should be placed in a sealed bag for appropriate trash disposal.
-- Place reusable gloves in a clean plastic bag and wash them in water containing detergent or disinfectant.
-- Thoroughly wash your hands with soap and water for 15-20 seconds.
2. Individuals with the greatest potential for occupational exposure to bird droppings are likely those performing building and security equipment maintenance (e.g., cleaning the roof, mechanical penthouses, ledges where birds roost or rest, or CCTV equipment and lighting) or landscaping (e.g., pruning, digging, spreading mulch). Supervisors should review work activities and consider the likelihood of disturbing bird droppings. Questions should be referred to POSHO, and POSHOs can request technical assistance from OBO/OM/SHEM.
DEAD BIRDS
3. The AI virus remains in the tissues of infected dead birds for some time. Therefore, contact with dead birds should be avoided and local veterinary or agricultural authorities should be notified to collect the bird carcass for disposal or testing. If contact with a bird carcass is unavoidable (for example, a cat brings a dead bird into the house), follow the guidance below:
-- Wear gloves and, if possible, remove the carcass with a shovel or other disposable or cleanable utensil. Under no circumstances should the bird be touched with bare hands.
-- Place the carcass in a plastic bag and seal it. Place this bag in another bag or a cardboard box.
-- If disposing of the carcass in the absence of other instructions, bury it in a location where it is unlikely to be disturbed by other animals.
-- Thoroughly wash your hands with soap and water for 15-20 seconds.
HOUSE CATS
4. A few domestic cats, in addition to pigs, tigers, leopards, ferrets, and stone martens (a weasel-like mammal), have been infected with AI. The cats are believed to have been infected by eating uncooked diseased birds. Although no human cases of AI have been associated with contact with AI-infected cats, the following measures are recommended if there has been a verified AI infection in birds within the region:
-- Keep domestic cats inside the house to avoid exposure to potentially infected birds.
-- Avoid all contact with stray cats and keep them outside the house.
-- Inform local veterinary authorities if your cat is sick and has possibly been in contact with birds.
-- Strictly follow normal cat care hygiene rules. When cleaning cat litter boxes, wear gloves and thoroughly wash your hands with soap and water immediately afterward.
References
http://www.cdc.gov/flu/avian/gen-info/facts.htm
http://www.cdc.gov/travel/other/avian_flu_indonesia.htm
http://www.cdc.gov/travel/seasia.htm#country
http://www.who.int/csr/disease/avian_influenza/avian_faqs/en/index.html
http://www.cdc.gov/travel/mideast.htmhttp://www.who.int/foodsafety/micro/avian1/en/
http://www.avma.org/public_health/influenza/avian_faq.asp
http://www.fao.org/ag/againfo/subjects/en/health/diseases-cards/avian_cats.html,
http://www.nwhc.usgs.gov/publications/wildlife_health_bulletins/WHB_05_03.jsp, or http://www.oie.int/eng/en_index.htm
Fact Sheets
United States International Engagement on Avian Influenza
Department of State, May 3, 2006
Advancing the Nation's Preparedness for Pandemic Influenza
Department of State, May 3, 2006
Avian Influenza: International Partnership To Meet a Global Threat
Department of State, April 4, 2006
Transportation Concerns Associated with a Pandemic
USINFO, March 13, 2006
Public Health and Health Care Delivery: Preparing for a Pandemic
USINFO, March 10, 2006
Avian influenza ("bird flu")
World Health Organization (WHO), January 2006
Questions and Answers About Avian Influenza (Bird Flu) and Avian Influenza A (H5N1) Virus
U.S. Centers for Disease Control (CDC), November 25, 2005
Avian Influenza
Department of Agriculture, November 2005
APEC Initiative on Avian Influenza
The White House, November 19, 2005
Food Safety Issues
World Health Organization (WHO), November 2005
Avian Influenza: An International Partnership To Meet A Global Threat
Department of State, November 2, 2005 (PDF 220k)
Avian Influenza (Bird Flu)
PandemicFlu.Gov, November 2, 2005
Safeguarding America Against Pandemic Influenza
The White House, November 1, 2005
How Does Seasonal Flu Differ From Pandemic Flu?
Department of Health and Human Services (HHS), November 1, 2005
Influenza Pandemics: How They Start, How They Spread, and Their Potential Impact
National Vaccine Program Office, Department of Health and Human Services (HHS), October 18, 2005
Ten Things You Need To Know About Pandemic Influenza
World Health Organization (WHO), October 14, 2005
WHO Guidance on Public Health Measures in Countries Experiencing Their First Outbreaks of H5N1 Avian Influenza
World Health Organization (WHO), October 2005
Avian Flu
Department of State, October 19, 2005
U.S. Outlines Actions To Prevent Human Flu Pandemic
Department of State, September 14, 2005
U.S. Government Agencies
PandemicFlu.gov
Avian Influenza Response
U.S. Agency for International Development (USAID)
Avian Influenza
U.S. Centers for Disease Control (CDC)
Avian Influenza (Bird Flu)
U.S. Department of Agriculture (USDA)
Animal and Plant Health Inspection Service (APHIS)
U.S. Department of Agriculture (USDA)
Avian Influenza Information
National Agricultural Library, U.S. Department of Agriculture
Avian Influenza
U.S. Department of Defense
National Vaccine Program Office
U.S. Department of Health and Human Services (HHS)
Avian Influenza
U.S.Department of State
Avian Influenza Frequently Asked Questions
Travel.State.Gov, Bureau of Consular Affairs, U.S. Department of State
Avian Flu
VOANews.com
Organizations
Avian Influenza
Animal Health Special Report, Food and Agriculture Organization of the United Nations(FAO)
Bi-weekly Avian Influenza Maps
Food and Agriculture Organization of the United Nations(FAO)
Fighting Bird Flu
Photo Gallery from the FAO
Avian Influenza
World Health Organization (WHO)
Avian Influenza
World Organisation for Animal Health
Update on Avian Influenza in Animals in Asia
World Organisation for Animal Health
Regional Health Threats: Avian Flu
Asia-Pacific Economic Cooperation (APEC)
South East Asian Nations Infectious Diseases Outbreak Surveillance Network
ASEAN-Disease-Surveillance.Net
Online Reading
H5N1 Avian Influenza: Timeline
World Health Organization (WHO) Februray 15, 2006
Video Conference
Dr. John Agwunobi, January 23, 2006
Broadband | Dial-up | Transcript
U.S. and International Responses to the Global Spread of Avian Flu: Issues for Congress
U.S. Congressional Research Service (CRS), Updated January 9, 2006 (PDF, 284 KB)
Key Facts About Avian Influenza (Bird Flu) and Avian Influenza A (H5N1) Virus
U.S. Centers for Disease Control and Prevention (CDC), October 25, 2005
Pandemic Influenza Response and Preparedness Plan
The White House, November 1, 2005
H5N1 - Killer Flu
Video documentary from PBS
Responding to the Avian Infuenza Pandemic Threat WHO, September 2005 (PDF, 22 pages)
Pandemics and Pandemic Scares in the 20th Century
U.S. Department of Health and Human Services (HHS)
OIE-FAO International Conference on Avian Influenza
Paris, France 7 - 8 April 2005
Avian Influenza Trade Ban Status as of 2-23-05 APHIS/USDA
Avian Influenza: Multiple Strains Cause Different Effects Worldwide
U.S. Congressional Research Service (CRS) Updated May 14, 2004
Guidance For Protecting Workers Against Avian Flu
U.S. Department of Labor, Occupational Safety & Health Administration
Avian Influenza A (H5N1) in 10 Patients in Vietnam
New England Journal of Medicine, March 18, 2004
Biosecurity for the Birds APHIS/USDA